Lysophosphatidic acid (LPA) 18:1 transcriptional regulation of primary human gingival fibroblasts
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چکیده
منابع مشابه
Lysophosphatidic acid (LPA) 18:1 transcriptional regulation of primary human gingival fibroblasts
The pleiotropic, bioactive lipid lysophosphatidic acid [(LPA), 1-acyl-sn-glycerol-3-phosphate] exerts critical regulatory actions in physiology and pathophysiology in many systems. It is present in normal bodily fluids, and is elevated in pathology (1). In vivo, "LPA" exists as distinct molecular species, each having a single fatty acid of varying chain length and degree of unsaturation covalen...
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Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1-6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female. Studies in various species of animals and also in humans have identified important roles for the receptor-mediated LPA signaling in multiple aspects of human and animal repr...
متن کاملLysophosphatidic acid (LPA) signaling in vertebrate reproduction.
Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA(1-5), and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects...
متن کاملLysophosphatidic acid (LPA) and its receptors.
Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist. Most of these receptors have been genetically deleted in mice toward identifying biological and medically relevant roles. In a...
متن کاملPrimary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA)
The plasma level of LPA (lysophosphatidic acid) (200-600 nM) is well within the range that promotes proliferation and migration of vascular ECs (endothelial cells), yet vessels are quiescent and stable. In this report, we considered one explanation for this paradox: that ECs secrete agents that attenuate responsiveness to LPA. Indeed, we observed that CM (conditioned medium) from confluent, qui...
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ژورنال
عنوان ژورنال: Genomics Data
سال: 2014
ISSN: 2213-5960
DOI: 10.1016/j.gdata.2014.10.014